Sendgrid Single Sender error message (using Node.js)

Has anyone ever come across this error when trying to use send grid just as a Single Sender not when smpt is set up with send grid? I didn’t wanna go through the worry of setting up smtp on domain as yet. I believe I might be missing something so I am calling on the community for help. Or, how did any of you manage to implement Sendgrid via middleware?

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