Grid settings

I have my design layouts set in XD using 5 viewport sizes, 375px, 768px, 1024px, 1366px, 1920px.
375 uses a 4 column grid, 768 and 1024 uses an 8 column… and 1366 and 1920 uses a 12 column.
My question is can I replicate this using Advanced theme manager. Subsequently I see I am able to adjust breakpoints, Can I also set different gutter widths for different breakpoints? Or do I need to revert to direct bootstarp adjustment with mixins and Sass

Thanks in advance